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The drug can also be melted in water and injected. Because the drug is meant to act as a time-released pain reliever, when crushed or injected oxycodone causes an intense high that involves feelings of euphoria. This is how abusers experience an oxycodone overdose, due to the large amount of the substance being released into their system at once, rather than slowly released over time in the oxycodone pill form.

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If a person's use of oxycodone is radically different from their prescription or doctor's recommendations, or is taken without a prescription, they may be addicted to the drug. Oxycodone abuse can be seen in those who have developed a dependence on the drug and will continue to take it despite negative consequences. Their bodies go through withdrawal when the intake of the drug is ceased. Withdrawal symptoms are quite obvious and include anxiety, diarrhea, nausea, muscle cramping, especially in the legs, and restlessness

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